Antimutagenic Activity of Cassia Auriculata Linn Fractions along with Anticancer Activity in Male Albino Mice

Background: In recent years, there has been a surge in interest studying plant-derived materials and their impact on DNA. Herbal products include number of natural substances that may help protect cells against mutagen-induced cell damage.
 Aim: The purpose this research was to assess the genotoxic effects Cassia Auriculata Linn flavonoids (CAF) saponin (CAS) rich fractions mouse bone marrow utilizing chromosomal aberration test micronucleus assay.
 Methodology: suppressive CAF CAS 7, 12-dimethylbenz (α) anthracene (DMBA) Croton oil induced skin tumor promotion mice with topical administration twice weekly for 18 weeks is also investigated work. Three dosages 100 200 mg/kg body weight were used. Single oral Fraction at three levels did not enhance micronucleate polychromatic erythrocytes experiment.
 Result: cells, single treatment fraction revealed no significant alterations mitotic indices or induction. clastogenicity CYP considerably decreased by pretreatment fraction. As result, it can be stated had cells.
 Conclusions: portions have shown non-genotoxic non-clastogenic quantities utilized investigation. might possibly promising reducing agent, according research.